Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes

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Al-Zubaidi U., Adhikari D., Cinar Ö., Zhang Q., Yuen W. S., Murphy M. P., ...More

HUMAN REPRODUCTION, vol.36, no.3, pp.771-784, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1093/humrep/deaa300
  • Journal Name: HUMAN REPRODUCTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Gender Studies Database, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.771-784
  • Keywords: aging, oocyte, spindle, chromosome, mitochondria-targeted therapeutics, ASSEMBLY CHECKPOINT, ANTIOXIDANT MITOQ, HUMAN ANEUPLOIDY, MATERNAL AGE, DOUBLE-BLIND, FERTILITY, SUPPLEMENTATION, COENZYME-Q10, DYSFUNCTION, INFERTILITY
  • Ankara University Affiliated: Yes

Abstract

STUDY QUESTION: Do mitochondria-targeted therapies reverse ageing- and oxidative stress-induced spindle defects in oocytes from mice and humans?