PERIPHERAL T-CELL RECEPTORS ALPHA-BETA AND GAMMA-DELTA IN PATIENTS WITH HODGKINS LYMPHOMA

AKAN H., BEKSAÇ M., AYDOGDU I., KOC H., ILHAN O., OZCAN M.

BRITISH JOURNAL OF HAEMATOLOGY, cilt.87, sa.3, ss.544-547, 1994 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87 Sayı: 3
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1111/j.1365-2141.1994.tb08310.x
  • Dergi Adı: BRITISH JOURNAL OF HAEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.544-547
  • Anahtar Kelimeler: TCR ALPHA-BETA, TCR GAMMA-DELTA, HODGKINS LYMPHOMA, DISEASE
  • Ankara Üniversitesi Adresli: Evet

Özet

Antigen recognition by T cells is determined by an antigen specific T cell receptor (TCR). Two heterodimeric TCR structures associated with CD3 have been defined: TCR alpha beta and TCR gamma delta. TCR alpha beta and its function are well described but the role of TCR gamma delta in normal and lymphoproliferative disorders is not well established. In newly diagnosed or relapsed/refractory Hodgkin's disease (HD), a disease associated with defective T cell functions and increased sIL-2R, we determined levels of seven TCR alpha beta variable regions [beta V5(a), beta V5(b), beta V6(a), beta V12(a), alpha beta V(a), alpha V2(a)] and TCR gamma delta by using monoclonal antibodies (MCA). TCR gamma delta levels did not show any difference, but several variable regions of the TCR alpha beta differed when groups are compared with each other and the control group.