Effect of taurine on hydrogen peroxide production in lipopolisaccharide induced RAW 264.7 macrophage cells

KARABAY A. Z., KOÇ A., ÖZKAN T., Büyükbingöl Z., SUNGUROĞLU A., AKTAN F.

Fabad Journal of Pharmaceutical Sciences, cilt.33, sa.4, ss.187-192, 2008 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 4
  • Basım Tarihi: 2008
  • Dergi Adı: Fabad Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.187-192
  • Anahtar Kelimeler: Hydrogen peroxide, LPS, Macrophage, Taurine
  • Ankara Üniversitesi Adresli: Evet

Özet

Taurine, one of the most abundant aminoacids in mammalian tissue, regulates various cellular functions, including membrane stabilization, antioxidation, calcium homeostasis maintenance and immunity. It is known that taurine has no significant effect on lipopolisaccharide (LPS) induced nitric oxide production in RAW 264.7 cells. In this study, we investigated the effect of taurine on hydrogen peroxide (H2O2) production in LPS induced RAW 264.7 macrophage cells. Nitrite and H2O2 levels in cell supernatants were determined spectrophotometrically. Our results show that taurine significantly decreases H2O2 levels without affecting nitrite production in LPS activated RAW 264.7 macrophages.