THE EFFECT OF NICARDIPINE ON RENAL FUNCTIONS FOLLOWING 72-HOUR COLD ISCHEMIA

KUZU M. A., KOKSOY C., ALACAYR I., YAZAR Ö., KUTERDEM E.

EUROPEAN SURGICAL RESEARCH, cilt.27, sa.5, ss.307-312, 1995 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 5
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1159/000129414
  • Dergi Adı: EUROPEAN SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.307-312
  • Anahtar Kelimeler: KIDNEY FUNCTIONS, COLD ISCHEMIA, CALCIUM CHANNEL BLOCKER, NICARDIPINE, ENHANCES VASCULAR-PERMEABILITY, CALCIUM, RAT, KIDNEY, MITOCHONDRIAL, VERAPAMIL, DILTIAZEM, FAILURE, RELEASE
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of the study was to investigate the cytoprotective effect of a calcium channel blocker, nicardipine, on altered renal function due to cold ischemia for 72 h. The experiments were performed on isolated perfused kidneys from adult rabbits. Kidneys were perfused with either standard Euro-Collins (EC) solution (n = 7) or EC containing nicardipine (n = 6) and then incubated with the same preservation solutions in a beaker exposed to cold ischemia for 72 h at +4 degrees C. In the control group the same procedure was applied to untreated kidneys (n = 6) which were exposed to cold ischemia for 30 min. Vascular responses and urinary output to noradrenaline, angiotensin II, endothelin-1, acetylcholine and sympathetic stimulation were assessed as the functional activities of the kidney. The responses of the preserved kidneys were compared following cold ischemic conditions. The results indicate that the addition of nicardipine to EC solution protects the vascular endothelial regulatory function and urine excretion; therefore, dihydropyridine calcium channel blockers might be useful for kidney preservation.