Akademik Veri Yönetim Sistemi
Turkish Journal of Pharmaceutical Sciences, cilt.10, sa.1, ss.9-17, 2013 (SCI-Expanded)
Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality in patients receiving renal replacement therapy and the antioxidant defense system in patients with renal failure is deteriorated. In order to evaluate the oxidative stress of Cyclosporin /Tacrolimus treatment.The analysis of fatty acid composition and lipid peroxide levels of HDL and Heme oxygenase(HO) activity assays were performed within the study to evaluate oxidative stress in renal transplant recipients in this study. 18 renal transplantation patients treated with Cyclosporin(CsA,n=6) and Tacrolimus(FK506,n=12) were studied and monitored for 120 days following transplantation.12 healthy volunteers composed the control group.In current study fatty acid composition and lipid peroxide levels of HDL and Heme oxygenase activity of lymphocytes were measured. The levels of total cholesterol, tryglyceride, HDL- and LDLcholesterol were also estimated.In FK506 group, C18:3 and C20:4 decreased significantly compared to control group(p<0.01.)C18:1 and C18:2 levels at 60th day in this group were also significantly higher than CsA group.Although the significant increase in HO activity at 60th day compared to control and before transplantation in CsA group(p<0.05), a significant decrease was observed at 120th day. There is no significant difference in FK506 group. The results showed that both groups were under oxidative stress after transplantation.Although the increase in HO activity sounds like it's the sign of antioxidant system is more favourable in CsA group, it was obvious that there was a relatively high oxidative stress in patients treated with CsA and it may be considered that the lipid profile of patients on FK506 therapy was more favorable than patients treated with CsA. The results show that oxidative stress is higher in Cyclosporin group.