Upregulation of beta(3)-adrenoceptors-a general marker of and protective mechanism against hypoxia?

Dal Monte M., Evans B. A., ARIOĞLU İNAN E., Michel M. C.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, cilt.393, sa.2, ss.141-146, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 393 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s00210-019-01780-6
  • Dergi Adı: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.141-146
  • Anahtar Kelimeler: beta(3)-Adrenoceptor, Upregulation, Hypoxia, Cancer, Congestive heart failure, Diabetes, ALTERED CONTRACTILE RESPONSE, BETA-ADRENOCEPTOR AGONISTS, BETA-3-ADRENERGIC RECEPTOR, NITRIC-OXIDE, BETA(3)-ADRENERGIC RECEPTOR, DESENSITIZATION, EXPRESSION, STIMULATION, TRANSCRIPTION, INVOLVEMENT
  • Ankara Üniversitesi Adresli: Evet

Özet

beta(3)-Adrenoceptors exhibit a restricted expression pattern, particularly in humans. However, they have been found to be upregulated in various cancers and under several conditions associated with hypoperfusion such as congestive heart failure and diabetes for instance in the heart and other tissues. These conditions are frequently associated with hypoxia. Furthermore, direct induction of hypoxia has consistently been reported to cause upregulation of beta(3)-adrenoceptors across various tissues of multiple species including humans, rats, dogs, and fish. While a canonical hypoxia-response element in the promoter of the human beta(3)-adrenoceptor gene may play a role in this, no such sequence was found in rodent homologs. Moreover, not all upregulation of beta(3)-adrenoceptor protein is accompanied by increased expression of corresponding mRNA, indicating that the upregulation may involve factors other than transcriptional changes. We propose that upregulation of beta(3)-adrenoceptors at the mRNA and/or protein level is a general marker of hypoxic conditions. Moreover, it may be an additional pathway whereby cells and tissues adapt to reduced oxygen levels.