Expression of IFITM1 in chronic myeloid leukemia patients

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AKYERLİ BOYLU C., BEKSAÇ M., Holko M., Frevel M., Dalva K., ÖZBEK U., ...More

LEUKEMIA RESEARCH, vol.29, no.3, pp.283-286, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1016/j.leukres.2004.07.007
  • Journal Name: LEUKEMIA RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.283-286
  • Keywords: chronic myeloid leukemia, IFITM1, RT-PCR, gene expression, GENE-EXPRESSION, MEMBRANE-PROTEIN, ALPHA, MICROARRAY, BIOLOGY, PCR
  • Ankara University Affiliated: Yes

Abstract

We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival. (C) 2004 Elsevier Ltd. All rights reserved.