Simultaneous determination of amlodipine besylate and rosuvastatin calcium in binary mixtures by voltammetric and chromatographic techniques

Karadas-Bakirhan N., Gümüştaş M., Uslu B., Özkan S. A.

IONICS, cilt.22, sa.2, ss.277-288, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s11581-015-1534-8
  • Dergi Adı: IONICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.277-288
  • Anahtar Kelimeler: Amlodipine besylate, Rosuvastatin calcium, Voltammetry, HPLC, UPLC, Determination, Pharmaceuticals, ELECTRODE, BEHAVIOR
  • Ankara Üniversitesi Adresli: Evet

Özet

Voltammetric and liquid chromatographic (LC) methods have been developed for the simultaneous determination of amlodipine besylate (AML) and rosuvastatin calcium (ROS) for the first time. Detailed electrochemical behavior and simultaneous voltammetric determination of AML and ROS were investigated in detail using glassy carbon electrode (GCE). High-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC) were also developed for the comparison. Voltammetric method exhibited linear dynamic responses for the simultaneous assay of AML and ROS in the concentration range between 0.006 and 2.85 mu g/mL and between 0.01 and 5.00 mu g/mL, with detection limits of 0.001 and 0.003 mu g/mL, respectively. On the other hand, LC methods presented a wider linearity range than that of the SWV method between 0.5 and 100 mu g/mL with the detection limits of 0.011 and 0.027 mu g/mL for AML and 0.034 and 0.042 mu g/mL for ROS by UPLC and HPLC techniques, respectively.