Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D2

S. Akarsu E., Mamuk S., CÖMERT A.

Epilepsy Research, vol.30, no.1, pp.63-68, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 1998
  • Doi Number: 10.1016/s0920-1211(97)00092-2
  • Journal Name: Epilepsy Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.63-68
  • Keywords: AH 6809, PGD2, PTZ seizure, Sodium selenite, Rat, ZK 118.182
  • Ankara University Affiliated: Yes

Abstract

This study was undertaken to evaluate the role of brain PGD2 activity during PTZ induced seizures in rats. Potentiation of endogenous PGD2 activity caused an anti-convulsant effect. Thus, after PGD2 injection (5 μg/icv) the latency of generalized tonic clonic convulsions was prolonged. ZK 118.182, a stable analogue of PGD2, dose-dependently inhibited the incidence and the intensity of seizures when injected at doses of 1-100 ng/icv. But on the other hand, inhibition of PGD2 activity either by a D- type PG receptor antagonist (AH 6809; 50 ng/icv) or by a PGD synthase inhibitor (sodium selenite; 0.2 μg/icv) produced a proconvulsant effect by increasing the incidence and the intensity of the seizures. These findings indicate that endogenous PGD2 activity in the brain may have a specific inhibitory role for the initiation and propagation of PTZ induced seizures in rats.