Insulinotropic activity of chromonyl-2,4-thiazolidinediones

Verspohl E. J., BOZDAĞ DÜNDAR O., Kaup R. M., Bauer K., Ertan R.

Medicinal Chemistry Research, cilt.18, sa.8, ss.665-670, 2009 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 8
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00044-008-9158-4
  • Dergi Adı: Medicinal Chemistry Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.665-670
  • Anahtar Kelimeler: 2,4-Thiazolidinediones, Antidiabetic agents, Chromone, Chromonyl-2,4- thiazolidinediones, Insulinotropic activity
  • Ankara Üniversitesi Adresli: Evet

Özet

Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, series of chromonyl-2,4-thiazolidinediones (Ia-e, IIa-e, and IIIa-e) were tested for their insulinotropic activities in INS-1 cells. Compounds IIb-d and IIId were very active even at a low concentration of 0.001 mg/ml. Compounds IIIa-c were active only at higher concentration (0.01 mg/ml). Increase of insulin release was observed in the presence of 5.6 mmol/l glucose. © 2008 Birkhäuser Boston.