Antibiotic-induced mesenteric adenopathy in an intussusception mouse model: A randomized, controlled trial

Spiro D., Schmidt J., Arnold D., Cartner S., Yagmurlu A.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol.41, no.1, pp.39-43, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1097/01.mpg.0000161041.80953.9e
  • Journal Name: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.39-43
  • Keywords: intussusception, mesenteric adenopathy, antibiotics, gastrointestinal system, NITRIC-OXIDE, ERYTHROMYCIN, LIPOPOLYSACCHARIDE, PATHOGENESIS, RATS, MICE
  • Ankara University Affiliated: No

Abstract

Background: Idiopathic intussusception is a leading cause of intestinal obstruction in young children. Although the etiology remains obscure, lymphoid hyperplasia is found in a majority of cases. Antibiotics, the most frequently prescribed medication class in the pediatric population, have been recently associated with intussusception. The authors sought to determine whether enteral antibiotic exposure influences the development of mesenteric adenopathy. bowel dilation or intussusception in an animal model.