The diffusion of nimesulide gel into synovial fluid: a comparison between administration routes

Erdogan F., Ergun H., Gokay N. S., Gulmez S. E., Bolay B., Tulunay F. C.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, cilt.44, sa.6, ss.270-275, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.5414/cpp44270
  • Dergi Adı: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.270-275
  • Anahtar Kelimeler: nimesulide, topical NSAIDs, osteoarthritis, pharmacokinetic, WOMAC, CYCLOOXYGENASE ACTIVITY, PHARMACOKINETICS, EFFICACY
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Nimesulide is available in gel formulation and applied mainly for topical pain management. However, its passage to the synovial fluid is not yet clear. The aim of this study was to evaluate if topical administered nimesulide passes into the synovial fluid and to compare its concentration with the oral nimesulide administration regimen.