The roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinib-resistant chronic myeloid leukemia cells

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Bozkurt S., ÖZKAN T., ÖZMEN F., Baran Y., SUNGUROĞLU A., Kansu E.

HEMATOLOGY, cilt.18, sa.4, ss.217-223, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1179/1607845412y.0000000056
  • Dergi Adı: HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.217-223
  • Anahtar Kelimeler: Epigenetic, DNA Methylation, CML, Policomb group proteins, POLYCOMB GROUP PROTEINS, DNA METHYLATION, HISTONE METHYLTRANSFERASE, CANCER, EXPRESSION, SIGNATURE, PROLIFERATION, PROGRESSION, CARCINOMA, APOPTOSIS
  • Ankara Üniversitesi Adresli: Evet

Özet

In chronic myeloid leukemia (CML), epigenetic modifications such as promoter hypermethylation and inactive histone modification are known mechanisms of drug resistance. In our study, we investigated the roles of promoter hypermethylation of BIM and BID genes and H3K27me3 histone modification on imatinib resistance.