Pregabalin Attenuates Carrageenan-Induced Acute Inflammation in Rats by Inhibiting Proinflammatory Cytokine Levels

KILIÇ F. S., KAYGISIZ B., AYDIN Ş., YILDIRIM C., KARİMKHANİ H., ÖNER K. S.

EURASIAN JOURNAL OF MEDICINE, cilt.50, sa.3, ss.156-159, 2018 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5152/eurasianjmed.2018.17261
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.156-159
  • Anahtar Kelimeler: Pregabalin, inflammation, anti-inflammatory effect, cytokines, rat, HYPERSENSITIVITY, GABAPENTIN, MECHANISMS, EXTRACT, MODELS, ACID, MICE
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-alpha (TNF-alpha) and interleukine-1 beta (IL-1 beta) acting as acute phase cytokines in inflammation, and antiinflammatory cytokine IL-10, in rats.