Ultra-sensitive electrochemical sensor based on tannic acid/iron/titanium oxide for the detection of tyrosine in real biological and food samples

ERK N., Naser M., Bouali W.

Microchemical Journal, cilt.208, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 208
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.microc.2024.112626
  • Dergi Adı: Microchemical Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Food Science & Technology Abstracts, Index Islamicus, Veterinary Science Database
  • Anahtar Kelimeler: Electrochemical sensor, Food samples, Iron chloride, Tannic acid, Titanium oxide, Tyrosine
  • Ankara Üniversitesi Adresli: Evet

Özet

This study demonstrates the development and application of an electrochemical sensor for the direct and sensitive detection of tyrosine (Tyro) in biological and food samples. The crystalline structure and surface morphology of the chloro-tetracarbon titanium dioxide composite (Fe@TA/TiO2) were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy-dispersive X-ray analysis (EDAX). The electrochemical performance of the sensor was evaluated through electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV). The sensor exhibited a remarkably low limit of detection (LOD) of 5.8 nM, with a broad linear detection range from 0.8 to 34.1 μM. Tyro was successfully detected in real samples, including human plasma, milk, and soybean, with high sensitivity and excellent recovery, even in the presence of potential interferences. The modified electrode also demonstrated outstanding stability, repeatability, and reproducibility. These findings suggest that the Fe@TA/TiO2-modified glassy carbon electrode (GCE) represents a novel and effective approach for Tyro detection.