Synthesis and antimicrobial activity of some novel 2-(p-substituted-phenyl)-5-substituted-carbonylaminobenzoxazoles

Arpaci O., Oren İ., Altanlar N.

FARMACO, cilt.57, sa.3, ss.175-181, 2002 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 3
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0014-827x(01)01143-0
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
  • Sayfa Sayıları: ss.175-181
  • Anahtar Kelimeler: benzoxazole, carbonylamino, synthesis, antimicrobial activity, MICROBIOLOGICAL ACTIVITY, BENZIMIDAZOLE DERIVATIVES, REVERSE-TRANSCRIPTASE, BENZOXAZOLES, AGENTS, OXAZOLO(4,5-B)PYRIDINES, ZIDOVUDINE, INHIBITOR, L-697,661, THERAPY
  • Ankara Üniversitesi Adresli: Evet

Özet

A series of 2-(p-substituted-phenyl)-5-substitued-carbonylamino benzoxazole derivatives (5-22) was synthesized and their antimicrobial activities determined in comparison to several control drugs. The synthesized compounds were tested in vitro against Staphylococcus aureus, Streptococcus faecalis and Bacillus subtilis as Gram-positive, Pseudomonas aeruginosa and Escherichia coli as Gram-negative bacteria and the yeast Candida albicans. Microbiological results showed that the compounds possessed a diffuse spectrum of antibacterial activity against these microorganisms. Compound 9 which bears a phenylacetamido moiety at position 5 and a 4-fluorophenyl group at the 2-position of benzoxazole ring was the most active derivative against S. aureus, S. faecalis and P. aeruginosa with a MIC value of 12.5 mug/ml. Compound 11 provided higher potency than the other tested compounds against B. subtilis at a MIC value of 12.5 mug/ml. Compounds 5-22 showed antifungal activity against C. albicans with MIC values between 50 and 12.5 mug/ml. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.