Creation of a neovascularized transplantation site by endothelial cell growth factor releasing polymer sponge in rats: Implications for tissue engineering

Elçin Y. M., Elçin A. E., Dixit V.

Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, York, United Kingdom, 16 - 19 July 2000, pp.20 identifier

  • Publication Type: Conference Paper / Full Text
  • City: York
  • Country: United Kingdom
  • Page Numbers: pp.20
  • Ankara University Affiliated: Yes

Abstract

Poly (DL-lactic-co-glycolic acid) (PLGA) sponge was designed to release this mitogen to create a highly vascular transplantation site for studies related to tissue engineering of liver of rats. PLGA sponge was prepared utilizing a particulate leaching technique with controlled pore size. PLGA sponges had a macroporous structure, together with micropores of <0.5 μm in size that would be suitable for the slow delivery of endothelial cell growth factor (ECGF). It was concluded that neovascularized cell transplantation sites can be created using ECGF-releasing PLGA sponges.