Comparison of Ellagic Acid and NSAI Agents in the Treatment of Achilles Tendon Lacerations: An Experimental Study in Rabbits

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ALLAHVERDİ E., ALLAHVERDİ T. D., VURAL S.

INTERNATIONAL SURGERY, vol.104, no.11-12, pp.575-581, 2019 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 104 Issue: 11-12
  • Publication Date: 2019
  • Doi Number: 10.9738/intsurg-d-19-00007.1
  • Journal Name: INTERNATIONAL SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.575-581
  • Keywords: Rabbit, Achilles tendon, Ellagic acid, NSAI
  • Open Archive Collection: AVESIS Open Access Collection
  • Ankara University Affiliated: Yes

Abstract

Objective: Although Achilles tendon ruptures can have many causes, they are known to develop most commonly with trauma. Nonsteroidal anti-inflammatory drugs (NSAID) and low doses of corticosteroids are used in the medical treatment of tendon ruptures. Ellagic acid (EA), which also has an anti-inflammatory effect, has been reported to show its effect via cyclooxygenase 2 (COX2) inhibition as well. The effects of EA and diclofenac sodium on tendon healing were compared in this study.