Synthesis and hypoglycemic activity of some new flavone derivatives - 3rd communication: 3 '-flavonyl-2,4-thiazolidinediones

Bozdag O., Verspohl E., Ertan R.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.50, sa.7, ss.626-630, 2000 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 7
  • Basım Tarihi: 2000
  • Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.626-630
  • Anahtar Kelimeler: antidiabetic agents, diabetes mellitus, insulin secretion, flavone derivatives, 2,4-thiazolidinediones, ALDOSE REDUCTASE, SUBSTITUTED THIAZOLIDINEDIONES, INHIBITION, RAT
  • Ankara Üniversitesi Adresli: Evet

Özet

A new series of 3'-flavonyl-2,4-thiazolidinedione, 2,4-imidazolidinedione and 2-thiohydantoin derivatives (1-10) were synthesized and their chemical structures have been elucidated by various spectral data. The prepared compounds were tested for their insulinotropic effects in INS-1 cells. Inhibitory effects were observed for compounds 1 and 2. In contrast compounds 4, 7 and 8 were able to increase insulin release compared with glibenclamide.