The early protective effects of L-arginine and Ng-nitro-L-arginine methyl ester after experimental acute spinal cord injury. A light and electron microscopic study

Yuceer N., Attar A., Sargon M., Egemen N., Turker R., Demirel E.

Journal of Clinical Neuroscience, cilt.7, sa.3, ss.238-243, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 3
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1054/jocn.1999.0210
  • Dergi Adı: Journal of Clinical Neuroscience
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.238-243
  • Anahtar Kelimeler: electron microscopy, L-arginine, Ng-nitro-L-arginine methyl ester, spinal cord injury, VASCULAR CORROSION CASTS, BLOOD-FLOW, 3-DIMENSIONAL ANALYSIS, OXIDE SYNTHASE, TRAUMA, RAT, METHYLPREDNISOLONE, NIMODIPINE, MECHANISMS, ISCHEMIA
  • Ankara Üniversitesi Adresli: Evet

Özet

The purpose of this study was to investigate the early protective effects of L-arginine and Ng-nitro-L-arginine methyl ester (L-NAME) after acute spinal cord injury. Acute spinal cord injury was performed by epidural application of an aneurysm clip at thoracic (T) 7-11 level. L-arginine at a dose of 750 μg/kg/min was administered 10 min before acute spinal cord injury and continued for 30 min to 10 animals (Group II). L-NAME at a dose of 250 μg/kg/min was administered 10 min before acute spinal cord injury and continued for 30 min to 10 animals (Group III). No drug was administered to 10 animals after acute spinal cord injury (Group I). Light and electron microscopic analysis were performed in all of the groups. Oedema of perineural, axoplasm or white matter in the L-arginine-treated group was less than in Group I and Group III. Thickening in the walls of the arterioles and venules in the L-arginine-treated group was much milder than in Group I and Group III. Degeneration of myelinated axons in the L-arginine-treated group was milder than in the control group. But there was no different between Group II and Group III. (C) 2000 Harcourt Publishers Ltd.