Anticancer effect of Ferulago Mughlea Peşmen (Apiaceae) on cancer cell proliferation

Filiz B., Karakaya S., Bostanlik D., Gul F., KILIÇ C. S.

Iranian Journal of Pharmaceutical Research, cilt.15, sa.3, ss.501-504, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2016
  • Dergi Adı: Iranian Journal of Pharmaceutical Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.501-504
  • Anahtar Kelimeler: Ferulago mughlea, Apiaceae, lyophilized extract, antiproliferative, cancer prostate, colorectal carcinoma, ESSENTIAL OIL, MEDICINAL-PLANTS, ROOTS, FRUITS, APOPTOSIS, COUMARINS, TURKEY
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2016 by School of Pharmacy.Ferulago W. Koch. (Apiaceae) genus is represented by approximately 50 taxa throughout the world. Ferulago species are known as “Çakşır” or “Çağşır” in Turkey and mostly known for their aphrodisiac effects. However recent reports emphasize the activity of various Ferulago species against cancer, as well. The aim of this study was to investigate the effect of lyophilized extract of F. mughlea Peşmen, a species endemic for Turkey, on cancer cell proliferation. For this purpose human prostate (PC-3) and colorectal (SW-480) carcinoma cells were used to evaluate the antiproliferative effects of Ferulago W. Koch and the measurements were performed via MTT test. Lyophilized extracts obtained from aerial parts and the roots exhibited potent inhibitor effects on cell proliferation. Aerial part of the plant inhibited the proliferation of SW-480 cell at 48th hour with a 0.119 mg/mL IC50 value.