Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

Abaan O. D., Mutlu P., Baran Y., Atalay C., Gunduz U.

CANCER INVESTIGATION, cilt.27, sa.2, ss.201-205, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/07357900802173562
  • Dergi Adı: CANCER INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.201-205
  • Anahtar Kelimeler: Multidrug resistance, MDR, MRP1, Breast cancer, Chemotherapy, MRP Family, HUMAN TUMOR-CELLS, LEUKEMIA-CELLS, PROTEIN MRP, DRUG-RESISTANCE, EXPRESSION, CARCINOMA, MDR1
  • Ankara Üniversitesi Adresli: Hayır

Özet

Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.