In Situ Hydrogel Formulation for Intra-Articular Application of Diclofenac Sodium-Loaded Polymeric Nanoparticles

KÜÇÜKTÜRKMEN B., ÖZ U. C., BOZKIR A.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.14, no.1, pp.56-64, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.4274/tjps.84803
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.56-64
  • Keywords: Diclofenac sodium, drug delivery, PLGA, Poly(epsilon-caprolactone), thermosensitive hydrogel, poloxamers, DRUG-DELIVERY, ENCAPSULATION EFFICIENCY, RELEASE, VITRO, SYSTEM, GELS, MICROSPHERES, CYTOTOXICITY, OPTIMIZATION, COPOLYMERS
  • Ankara University Affiliated: Yes

Abstract

Objectives: The world's population is getting older and the number of people suffering from arthritis is a major problem according to World Health Organization's data. In this respect, the need for more efficient treatment for arthritis becomes an urgent issue. In this research, nanoparticle bearing in situ gelling hydrogel formulation was developed for prolonged local delivery of diclofenac sodium (DS).