In Situ Hydrogel Formulation for Intra-Articular Application of Diclofenac Sodium-Loaded Polymeric Nanoparticles

KÜÇÜKTÜRKMEN B., ÖZ U. C., BOZKIR A.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, sa.1, ss.56-64, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjps.84803
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.56-64
  • Anahtar Kelimeler: Diclofenac sodium, drug delivery, PLGA, Poly(epsilon-caprolactone), thermosensitive hydrogel, poloxamers, DRUG-DELIVERY, ENCAPSULATION EFFICIENCY, RELEASE, VITRO, SYSTEM, GELS, MICROSPHERES, CYTOTOXICITY, OPTIMIZATION, COPOLYMERS
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: The world's population is getting older and the number of people suffering from arthritis is a major problem according to World Health Organization's data. In this respect, the need for more efficient treatment for arthritis becomes an urgent issue. In this research, nanoparticle bearing in situ gelling hydrogel formulation was developed for prolonged local delivery of diclofenac sodium (DS).