Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer
TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.3, ss.1465-1471, 2021 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.3906/sag-2007-254
- Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1465-1471
- Anahtar Kelimeler: Genistein, GSK-3, IL-6, TNF-alpha, laying hens, ovarian cancer, GLYCOGEN-SYNTHASE KINASE-3-BETA, BETA-CATENIN, EXPRESSION, RISK, METASTASIS, INHIBITION, ACTIVATION, SURVIVAL, RECEPTOR, CELLS
- Ankara Üniversitesi Adresli: Evet
Özet
Background/aim: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer.