Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer

Erten F., YENİCE E., ORHAN C., Besir E. R., Demirel Oner P., Defo Deeh P. B., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.3, ss.1465-1471, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/sag-2007-254
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1465-1471
  • Anahtar Kelimeler: Genistein, GSK-3, IL-6, TNF-alpha, laying hens, ovarian cancer, GLYCOGEN-SYNTHASE KINASE-3-BETA, BETA-CATENIN, EXPRESSION, RISK, METASTASIS, INHIBITION, ACTIVATION, SURVIVAL, RECEPTOR, CELLS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background/aim: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer.