Expression and Signaling of beta-Adrenoceptor Subtypes in the Diabetic Heart

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Erdogan B. R., Michel M. C., ARIOĞLU İNAN E.

CELLS, cilt.9, sa.12, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 9 Sayı: 12
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3390/cells9122548
  • Dergi Adı: CELLS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals
  • Anahtar Kelimeler: diabetes, heart, beta adrenoceptor, ADENYLATE-CYCLASE ACTIVITY, NITRIC-OXIDE SYNTHASE, ALTERED CONTRACTILE RESPONSE, ALDOSE REDUCTASE INHIBITION, DEPENDENT PROTEIN-KINASE, ADRENERGIC-RECEPTORS, RAT-HEART, UP-REGULATION, IN-VIVO, BETA(3)-ADRENOCEPTOR STIMULATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Diabetes is a chronic, endocrine disorder that effects millions of people worldwide. Cardiovascular complications are the major cause of diabetes-related morbidity and mortality. Cardiac beta(1)- and beta(2)-adrenoceptor (AR) stimulation mediates positive inotropy and chronotropy, whereas beta(3)-AR mediates negative inotropic effect. Changes in beta-AR responsiveness are thought to be an important factor that contributes to the diabetic cardiac dysfunction. Diabetes related changes in beta-AR expression, signaling, and beta-AR mediated cardiac function have been studied by several investigators for many years. In the present review, we have screened PubMed database to obtain relevant articles on this topic. Our search has ended up with wide range of different findings about the effect of diabetes on beta-AR mediated changes both in molecular and functional level. Considering these inconsistent findings, the effect of diabetes on cardiac beta-AR still remains to be clarified.