Synthesis and antioxidant properties of novel benzimidazoles containing substituted indole or 1,1,4,4-tetramethyl-1,2,3,4-tetrahydro-naphthalene fragments

ALAGÖZ Z., Kus C., Coban T.

Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.20, sa.4, ss.325-331, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/14756360500131706
  • Dergi Adı: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.325-331
  • Anahtar Kelimeler: benzimidazole, indole, retinoids, synthesis, free radical, antioxidant, ATOMIC PHYSICOCHEMICAL PARAMETERS, QUANTITATIVE STRUCTURE, LIPID-PEROXIDATION, DERIVATIVES, INHIBITORS
  • Ankara Üniversitesi Adresli: Evet

Özet

Some 6-fluoro-5-substituted-benzimidazole derivatives in which indole and 1,1,4,4-tetramethyl-1,2,3,4-tetrahydro-naphthalene groups were attached to the 2-position of the benzimidazole ring were synthesized and tested for antioxidant properties in vitro. Almost all the synthesized compounds at the 10-3 M concentrations showed superoxide anion scavenging activity. Compounds 5, 3, 9, 4, 17 and 13 have strong inhibitory effects on superoxide anion formation (98%, 93%, 91%, 88%, 85% and 81%, respectively) at 10-3 M concentration and these results are better than 30 IU of superoxide dismutase (SOD) (76%). Compound 11 is the most effective scavenger of 2,2-diphenyl-1-picrylhydrazyl (DPPH) stable free radical at 10-3 M (61%) concentration. © 2005 Taylor & Francis.