Akademik Veri Yönetim Sistemi
XXIII Meeting of the Federation of European Physiological Societies and XLI Meeting of the Spanish Society for Physiological Sciences, Granada, İspanya, 4 - 06 Eylül 2024
Introduction/Objetives: Rapid and coordinated processing of space, time and number is fundamental for the daily flow of life. ATOM theory proposes these perceptions are processed in partially overlapping brain areas as a magnitude system. We aimed to combine the results of fMRI studies conducted on space, time and number perception using a coordinate-based meta-analysis approach, to show overlapping brain areas.
Materials and methods: We conducted three separate literature searches for space, time, and number perceptions in accordance with PRISMA guidelines. 19 articles for space perception, 38 for time perception, and 31 for number perception were identified as suitable for meta-analysis. Coordinates taken from the articles were subjected to meta-analysis through the "GingerALE" program using "Activation Likelihood Estimation" statistical method. A total of 7 meta-analysis results were obtained through single dataset and conjunction analyses.
Results: Fronto-parietal dominated activation maps were obtained in space, time and number perceptions; additionally basal ganglia activations were predominant in time perception. In double conjunction analyses, fronto-parietal and insular activations were noted. The triple conjunction analysis showed activations in the right inferior parietal, inferior frontal and anterior insular cortex.
Conclusion: Our results support that space, time and number perceptions occur through partially overlapping neural networks. The parietal and prefrontal cortex regions shown in the triple conjunction analysis were previously suggested as significant cortical areas in the ATOM theory. The insula is associated with interoception and salience and has been reported in previous studies related to space, time and number perceptions. Our results are in support of the ATOM theory.