Synthesis of highly <i>N</i>-substituted indole library via conjugate additions of indoline and their synthetic tool potentials

KILIÇ, Haydar; Bayindir, Sinan; Erdogan, Esra; SARAÇOĞLU, NURULLAH

doi:10.1016/j.tet.2012.04.066

Synthesis of highly <i>N</i>-substituted indole library via conjugate additions of indoline and their synthetic tool potentials

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KILIÇ H., Bayindir S., Erdogan E., SARAÇOĞLU N.

TETRAHEDRON, vol.68, no.27-28, pp.5619-5630, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 68 Issue: 27-28
Publication Date: 2012
Doi Number: 10.1016/j.tet.2012.04.066
Journal Name: TETRAHEDRON
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
Page Numbers: pp.5619-5630
Ankara University Affiliated: No

Abstract

A comprehensive library of N- or 1-substituted indoles was formed by conjugate additions of indoline with Michael acceptors followed by an oxidation step. Using N-substituted indoles as key Michael donors, the synthesis of 1,3-disubstituted indoles was also accomplished. (c) 2012 Elsevier Ltd. All rights reserved.