Maternal Serum and Umbilical Cord Brain Natriuretic Peptide Levels in Fetuses with Intrauterine Growth Restriction

Eroglu H., Erdol M. A., Tonyali N. V., Orgul G., Biriken D., Yucel A., ...Daha Fazla

FETAL AND PEDIATRIC PATHOLOGY, cilt.41, sa.5, ss.722-730, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/15513815.2021.1955057
  • Dergi Adı: FETAL AND PEDIATRIC PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.722-730
  • Anahtar Kelimeler: Pregnancy, proBNP, intrauterine growth restriction, cord blood sample, FETAL-GROWTH, PREECLAMPSIA, NEURODEVELOPMENT, PREGNANCY, TERM
  • Ankara Üniversitesi Adresli: Evet

Özet

Aim We compared maternal serum and fetal cord blood proBNP levels in healthy pregnancies to those with intrauterine growth restriction (IUGR). Methods: Prospectively, maternal and cord blood samples at childbirth of 40 pregnant women with isolated IUGR and 40 healthy pregnant women were evaluated for ProBNP levels. Results: The mean serum ProBNP level was significantly higher in newborn cord blood with IUGR than in the control group (181.28 +/- 145.37 vs. 91.41 +/- 49.77 pg/mL, p = <0.01). Mean serum ProBNP level trended higher in women with IUGR compared to the controls, but was not statistically significant (124.21 +/- 113.32 vs. 88.73 +/- 85.18 pg/mL, p= >0.05). Conclusion: Third trimester mean proBNP in fetal cord blood are increased in IUGR fetuses at term birth compared to pregnancies with normal fetal growth.