Synthesis and Antimicrobial Activity of New Tetrahydro-Naphthalene-Thiazolidinedione and Thiohydantoine Derivatives

ALAGÖZ Z., Altanlar N., Buyukbingol E.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.46, sa.6, ss.1375-1379, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/jhet.256
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1375-1379
  • Ankara Üniversitesi Adresli: Evet

Özet

As part of an ongoing program aimed at recognizing novel antioxidant, antimicrobial, and anticancer molecules, herein we report the synthesis and biological evaluation of imidazolidin-4-one and thiazolidine-2,4-dione derivatives as antimicrobial agents. These compounds were prepared from 5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-carboxaldehyde and 3-substituted phenacyl-2,4-thiazolidinediones using Knoevenagel reaction. The structures of compounds were confirmed by H-1 NMR, mass spectral data, and elemental analyses. The molecules were evaluated for in vitro antimicrobial activity against methicillin-resistant Staphylococcus aureus (NMSA) (standard), methicillin-resistant Staphylococcus aureus (isolated), Staphylococcus aureus (SA), Escherichia coli (EC), Bacillus subtilis (BS), and Candida albicans (CA). Compounds 3(a-g) and compound 4 showed equal and/or greater antimicrobial activity against MRSA and EC than ampicillin and sultamicillin.