Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells: An immuno electron microscopic study

Seftalioglu, A; Karakus, S; Dundar, S; Can, BELGİN; Erdemli, ESRA; Irmak, MK; Oztas, E; Korkmaz, C; Yazar, F; Cavusoglu, I

doi:10.1080/0891060310002267

Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells: An immuno electron microscopic study

Seftalioglu A., Karakus S., Dundar S., Can B., Erdemli E., Irmak M., ...Daha Fazla

Acta Oncologica, cilt.42, sa.1, ss.71-74, 2003 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 42 Sayı: 1
Basım Tarihi: 2003
Doi Numarası: 10.1080/0891060310002267
Dergi Adı: Acta Oncologica
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.71-74
Ankara Üniversitesi Adresli: Evet

Özet

Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known; its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.