Association between the dosage and duration of statin treatment with coronary collateral development

DİNÇER İ., ONGUN A., Turhan S., Ozdol C., KUMBASAR S. D., Erol Ç.

CORONARY ARTERY DISEASE, cilt.17, sa.6, ss.561-565, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1097/00019501-200609000-00010
  • Dergi Adı: CORONARY ARTERY DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.561-565
  • Anahtar Kelimeler: angiogenesis, coronary angiography, coronary artery disease, HMG CoA reductase inhibitors, ARTERY-DISEASE, HYPERCHOLESTEROLEMIA, CIRCULATION, FLOW, ANGIOGENESIS, PRAVASTATIN
  • Ankara Üniversitesi Adresli: Evet

Özet

Background The coronary collateral circulation is an alternative source of blood supply to myocardium in the presence of advanced coronary artery disease and the therapeutic promotion of collateral growth appears to be a valuable treatment strategy in these patients. Although it has been shown in in-vivo studies that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) promote vasculogenesis and accelerate coronary collateral development in ischemic tissues, there are discordant results in clinical studies. Our aim was to investigate the effect of statin therapy, including dosage and duration of treatment, on coronary collateral growth in patients with advanced coronary artery disease.