Akademik Veri Yönetim Sistemi
Praktische Tierarzt, cilt.86, sa.3, ss.188-195, 2005 (SCI-Expanded)
Puerperal and postpuerperal endometritis are responsible for severe economic loss by reducing milk yield and fertility. Aims of the present study were to compare efficacy of intrauterine instillation of Eucacomp® and Lotagen®, respectively, and to investigate their effects on fertility. According to the time of treatment, 141 cows were assigned to group I (n=81; early treatment: Day 22 to 63 p.p.) or to group II (n=60; late treatment: Day 78 to 147). The animals of both groups were dedicated to one of three treatments: A - Eucacomp® (intrauterine administration; n=52), B - Iliren® (intramuscularly) and three days later Eucacomp® (intrauterine; n=38) und C - Lotagen® (intrauterine; n=51). Severity of endometritis was determined by use of a scoring system according to Berchtold (1982). In 69.2 % (36/52) of Eucacomp®-treated cows pregnancies were obtained, whereas GTR in the Lotagen®-treated group yielded 56.9 % (29/51). Intervals from treatment to successful breeding were significantly shorter in cows of group A (47.8 ± 27.6 days) than of group C (70.6 ± 55.6 days) (P < 0.05). In group I, treatment with Eucacomp®, solely and combined with the PGF2α- analogue, yielded significantly shorter intervals from treatments to pregnancies as well as a significantly higher pregnancy rate than administration of Lotagen® (75.0 vs. 59.3 %, P < 0.05). In contrast, pregnancy rates did not differ among treatments of group II, but both Eucacomp® - treatments resulted in significantly lower BTI. According to severity of endometritis efficacy of therapies varied. While therapies did not differ significantly concerning intervals from treatments to subsequent pregnancies or GTR in cases of mild endometritis, application of Eucacomp® turned out to be more successful in moderate and severe endometritis. Animals with moderate endometritis conceived 57.0 ± 31.8 days after instillation of Eucacomp® yielding a GTR of 68.2 % (15/22). Eleven out of 20 Lotagen®-treated cows (55.0 %; P > 0.05) became pregnant 84.6 ± 20.4 days after treatment (P < 0.05). In cases of severe endometritis, Eucacomp®-treated cows were inseminated much earlier (37.2 ± 14.9 vs. 71.4 ± 41.3 days; P < 0.05) and with more success (GTR: 54.5 vs. 38.0 %) than in Lotagen®-treated cows. Supplementary administration of PGF2α (group B) did not yield apparent advantages. Results did not differ from those obtained after sole application of Eucacomp®. © Schlütersche Verlagsgesellschaft mbH & Co. KG.