Study on the determination of clozapine by voltammetry

Ozkan S. A., Senturk Z.

Analusis, cilt.24, sa.3, ss.73-75, 1996 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 1996
  • Dergi Adı: Analusis
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.73-75
  • Anahtar Kelimeler: clozapine, oxidation, activated glassy carbon electrode, tablets, SOLID-PHASE EXTRACTION, LIQUID-CHROMATOGRAPHY, GLASSY-CARBON, HUMAN-SERUM, DESMETHYLCLOZAPINE, ELECTRODES, DRUGS, URINE
  • Ankara Üniversitesi Adresli: Evet

Özet

The oxidative behavior of clozapine was studied as a function of pH at a glassy carbon electrode activated by applying a new pretreatment. The oxidation process was shown to be irreversible. The characteristics of the corresponding electrode reaction were discussed. A voltammetric method was developed at pH 4.5 (acetate buffer) for the quantitative determination of clozapine. The peak current was linear with the clozapine concentration in the range 2 10-6 M-8 10-4 M. The method was applied to the assay of clozapine tablets. © Elsevier.