Study of the carcinogenicity of large doses of dimethylnitramine, n-nitroso-l-proline, and sodium nitrite administered in drinking water to rats

Patil K., Bulay O., Runge R. G.

Journal of the National Cancer Institute, cilt.64, sa.6, ss.1435-1442, 1980 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 6
  • Basım Tarihi: 1980
  • Doi Numarası: 10.1093/jnci/64.6.1435
  • Dergi Adı: Journal of the National Cancer Institute
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1435-1442
  • Ankara Üniversitesi Adresli: Hayır

Özet

Large doses of dimethylnitramine (DMNM), N- nitroso-L-proline (NPRO), and sodium nitrite were administered in the drinking water to MRC Wistar rats for at least 1 year, and the rats were maintained for life. DMNM (total dose, 20 g/kg) produced liver tumors in 25 (69%) of 36 rats and nasal cavity tumors in 9 (25%) of the rats. NPRO (total dose, 36 g/kg) induced no tumors in 37 treated rats. In the group receiving NaNO2 (3.0 g/liter drinking water; total dose, 63 g/kg), 8 (18%) of 45 rats had forestomach squamous papillomas. The tumor incidence in the NaNO2-treated group was significantly greater than that of 2% in a control group started 11 months earlier, which suggested that the NaNO2 was tumorigenic in this experiment. © 1980 Oxford University Press.