REGIOISOMERIC N-ALKYLATION OF SOME INDAZOLES BAZI İNDAZOLLERİN REGİOİZOMERİK N-ALKİLASYONU

DOĞANÇ F., GÖKER A. H.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.49, sa.1, 2025 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.33483/jfpau.1571272
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
  • Anahtar Kelimeler: 2-benzodiazole), HMBC, indazole (1, NOESY, regioisomers
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Indazole scaffold have two interconvertible tautomeric forms. Based on our previous studies, regioisomeric N-alkylation of some indazole analogs was synthesized in this study and their structures were elucidated by 2D NMR methods. Material and Method: Regioisomers were resolved for N-benzylations and alkylation of some non-substituted and substituted indazoles, under basic conditions (K2CO3) in DMF. Result and Discussion: It was observed that, their occurrence ratios of N1: N2 is almost equal (50%). Their structures were established by combination of 1H-1H NOE (Nuclear Overhauser Effect Spectroscopy, NOESY) and HMBC (Heteronuclear Multiple Bond Correlation) NMR methods.