Akademik Veri Yönetim Sistemi
Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi, cilt.20, sa.1, ss.21-26, 2014 (Scopus)
Background: The effects of fentanyl and remifentanil in coronary artery bypass grafting (CABG) on drug consumption and costs, hemodynamics, extubation time, length of ICU stay and patient satisfaction have been compared in this study. Material and Methods: Sixty ASA III-IV CABG patients between 40 and 65 years of age were enrolled in the study.. Exclusion criteria were: patient's refusal to participate in the study, BMI > 30, uncontrolled hemodynamics, ejection fraction < 25%, need for intraaortic balloon pump, major organ dysfunction and planning of additional surgery. Group F received 2-3 mg kg -1 propofol, rocuronium 0.6 mg kg-1, fentanyl 5-10 μg kg-1 while Group R 2-3 mg kg-1 propofol, rocuronium 0.6 mg kg-1, remifentanil 1-2 μg kg-1 for induction. Group F received 2-3% sevoflurane, 50% oxygen-air, fentanyl 0.1-0.5 μg kg -1 min-1, 5 μg kg-1 fentanyl bolus before -sekonderin incision and sternotomy, Group R received 2-3% sevoflurane, 50% oxygen-air, remifentanil 0.5-1 μg kg-1 min -1, 0.25-1 μg kg-1 remifentanil bolus before incision and sternotomy. Patients received 5-10 μg kg-1 min -1 propofol until transfer to the ICU and BIS lowered to < 60.VAS. Ramsey scores, side effects, opioid consumption and costs, length of stay in the ICU, patient satisfaction at postextubation 1, 2, 4, 6, 12, 24th hours and Aldrete score at 1st hour were recorded Results: Heart rate was lower in Group R except for the preinduction period. MAP was lower in Group R from the preinduction to the first hour of the ICU -stay. Extubation times were similar between groups. Opioid consumption and cost -were lower in Group F. Conclusion: Results of this study show that intraoperative low- dose fentanyl appears to be a promising agent when hemodynamics and total opioid consumption are concerned.