Akademik Veri Yönetim Sistemi
STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA, cilt.70, sa.4, ss.263-274, 2025 (SCI-Expanded, Scopus)
This study investigated the in vitro inhibitory potential of the methanol extract of the aerial parts of Nepeta cadmea on α-glucosidase and α-amylase, which are known as key enzymes related to type 2 diabetes mellitus. To determine the active constituents of the endemic Lamiaceae plant, validated RP-HPLC and HPTLC techniques were used. The methanol extract demonstrated moderate and dose-dependent inhibitory activity, with inhibition rates of 43.57 ± 4.32% against α-glucosidase at 2 mg/mL and 36.74 ± 7.23% against α-amylase at 1 mg/mL. Phytochemical analysis revealed that rosmarinic acid (0.6290 ± 0.0095 g/100g dw) was the predominant phenolic compound, followed by chlorogenic acid (0.0429 ± 0.0012 g/100g dw) and caffeic acid (0.0027 ± 0.0002 g/100g dw). These findings suggest that this endemic Lamiaceae plant may have potential as a natural therapeutic agent for managing diabetes mellitus. Further studies are warranted to explore its mechanisms of action and to evaluate its efficacy in clinical settings.