Role of postmastectomy radiation therapy after neoadjuvant chemotherapy in locally advanced breast cancer

AKYÜREK S., Yavas G.

Experimental Oncology, cilt.35, sa.4, ss.267-271, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 35 Sayı: 4
  • Basım Tarihi: 2013
  • Dergi Adı: Experimental Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.267-271
  • Anahtar Kelimeler: Breast cancer, Locally advanced, Neoadjuvant chemotherapy, Radiotherapy
  • Ankara Üniversitesi Adresli: Evet

Özet

Neoadjuvant chemotherapy for primary breast cancer is the gold standard in the treatment of locally advanced, inoperable breast cancer, and also based on a large body of evidence has become a standard treatment option for patients with operable disease, who are clear candidates for adjuvant chemotherapy. There are several advantages of administering neoadjuvant chemotherapy: tumor downstaging, improving the chance of breast conserving surgery, in vivo assessment of tumor sensitivity to the chosen therapeutic regimen, and early control of micro-metastatic disease. However there are substantially less data to aid in determining which patients treated with neo-adjuvant chemotherapy warrant postmastectomy radiotherapy. According to the recent literature, patients who require mastectomy after systemic therapy should receive postmastectomy radiotherapy. Copyright © Experimental Oncology, 2013.