Role of postmastectomy radiation therapy after neoadjuvant chemotherapy in locally advanced breast cancer
Experimental Oncology, cilt.35, sa.4, ss.267-271, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 35 Sayı: 4
- Basım Tarihi: 2013
- Dergi Adı: Experimental Oncology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.267-271
- Anahtar Kelimeler: Breast cancer, Locally advanced, Neoadjuvant chemotherapy, Radiotherapy
- Ankara Üniversitesi Adresli: Evet
Özet
Neoadjuvant chemotherapy for primary breast cancer is the gold standard in the treatment of locally advanced, inoperable breast cancer, and also based on a large body of evidence has become a standard treatment option for patients with operable disease, who are clear candidates for adjuvant chemotherapy. There are several advantages of administering neoadjuvant chemotherapy: tumor downstaging, improving the chance of breast conserving surgery, in vivo assessment of tumor sensitivity to the chosen therapeutic regimen, and early control of micro-metastatic disease. However there are substantially less data to aid in determining which patients treated with neo-adjuvant chemotherapy warrant postmastectomy radiotherapy. According to the recent literature, patients who require mastectomy after systemic therapy should receive postmastectomy radiotherapy. Copyright © Experimental Oncology, 2013.