Risk Factors for Recurrence in Low-Risk Endometrial Cancer: A Case-Control Study

Gungorduk K., Cuylan Z. F., Kahramanoglu I., ÖGE T., Akbayir O., Dede M., ...Daha Fazla

ONCOLOGY RESEARCH AND TREATMENT, cilt.41, sa.7-8, ss.466-470, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 7-8
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1159/000488112
  • Dergi Adı: ONCOLOGY RESEARCH AND TREATMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.466-470
  • Anahtar Kelimeler: Low-risk endometrial cancer, Lymphovascular space invasion, Primary tumor diameter, LYMPH-NODE METASTASIS, CLINICAL STAGE-I, PROGNOSTIC-FACTORS, RADIATION-THERAPY, SCORING SYSTEM, TUMOR SIZE, ADENOCARCINOMA, PREDICTORS, CARCINOMA, SURVIVAL
  • Ankara Üniversitesi Adresli: Evet

Özet

Aim: The aim of this study was to investigate the risk factors for recurrence in patients with low-risk endometrial cancer (EC). Patients and Methods: This retrospective study was performed using 10 gynecological oncology department databases. Patients who met the following criteria were included in the study: (a) endometrioid- type histology, (b) histological grade 1 or 2, (c) no or <50% myometrial invasion, (d) no intraoperative evidence of extrauterine spread, and (e) the patient underwent at least a pelvic lymphadenectomy. Recurrence was detected in 56 patients who were histologically diagnosed with low-risk EC, and these patients made up the case group. A total of 224 patients with low-risk EC without recurrence were selected (control group) using a dependent random sampling method. The case and control groups were match-paired in terms of grade, stage, and operative technique. Results: Lymphovascular space invasion (LVSI) (odds ratio (OR) 5.8, 95% confidence interval (CI) 2.0-16.9; p = 0.001) and primary tumor diameter (PTD) >= 20 mm (OR 6.6, 95% CI 2.7-15.8; p < 0.001) were found to be independent risk factors for recurrence in women with low-risk EC. Conclusion: The presence of LVSI and PTD >= 20 mm seem to be significant risk factors for recurrence in women with low-risk EC. (C) 2018 S. Karger GmbH, Freiburg