A combination of non-invasive tests for the detection of significant fibrosis in patients with metabolic dysfunction-associated steatotic liver disease is not superior to magnetic resonance elastography alone

Duman S., Kuru D., Gumussoy M., KİREMİTCİ S., GÖKCAN H., Ulas B., ...Daha Fazla

EUROPEAN RADIOLOGY, cilt.34, sa.6, ss.3882-3888, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 6
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s00330-023-10441-5
  • Dergi Adı: EUROPEAN RADIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.3882-3888
  • Anahtar Kelimeler: Magnetic resonance elastography, Metabolic dysfunction-associated steatohepatitis, Metabolic dysfunction-associated steatotic liver disease, Non-invasive, Nonalcoholic fatty liver disease
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives The aims of the present study were to investigate a combination of magnetic resonance elastography (MRE) and vibration-controlled transient elastography (VCTE) or MRE and fibrosis score 4 (FIB-4) in the detection of significant fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).Methods Between November 5, 2021, and March 4, 2022, a total of 119 consecutive patients with MASLD were included. Liver stiffness was measured using liver biopsy, MRE, VCTE, and FIB-4. Data were collected from outpatient visit charts. Significant fibrosis was defined as >= stage 2 fibrosis.Results All 119 MASLD patients were Caucasian, and their median age was 55 years. MRE, VCTE, and FIB-4 demonstrated significant accuracy in the detection of significant fibrosis with an area under the ROC curve (AUC) of 0.848 +/- 0.036 (p < 0.001), 0.632 +/- 0.052 (p = 0.012), and 0.664 +/- 0.051 (p = 0.001), respectively. However, the diagnostic performance of MRE was superior compared to that of VCTE (AUC difference: 0.216 +/- 0.053, p < 0.001) and FIB-4 (AUC difference: 0.184 +/- 0.058, p = 0.001). With logistic regression analysis, it was determined that when compared to MRE alone, a combination of MRE and TE (p = 0.880) or MRE and FIB-4 (p = 0.455) were not superior for detecting significant fibrosis.Conclusions MRE alone is an accurate and non-invasive method for the identification of MASLD patients with significant fibrosis.