Akademik Veri Yönetim Sistemi
Journal of Molecular Structure, cilt.1373, 2026 (SCI-Expanded, Scopus)
Herein, trans- and cis-monocyclotetrachlorobis(ethyl-4-fluorobenzylspiro)cyclotetraphosphazenes (2 and 3) were synthesized from the reactions of octachlorocyclotetraphosphazene (OCCP), N4P4Cl8 (1) with two equimolar of N-ethyl-N′-(4-fluorobenzyl)-1,2-diaminoethane (L1). Trans-monocyclodispiro2 was treated with excess n-propylamine, n-butylamine, n-hexylamine, benzylamine and isopropylamine to obtain the monocyclo(4a-4e) and bicyclo(5a-5e) cyclotetraphosphazenes, respectively. Spectroscopic, crystallographic (for 4d) and thermal properties of all the cyclotetraphosphazenes were investigated. Furthermore, the products were screened for their antibacterial and antifungal activities against G(+)/G(-) bacteria and yeasts, interactions with pBR322 plasmid DNA and antituberculosis activities against Mycobacterium tuberculosis H37Rv strain. Particularly, compounds 5c and 5d (20 μg/mL), 5a (10 μg/mL), 4b and 5b (<1 μg/mL) were found to be highly sensitive to M. tuberculosis H37Rv. When the results were compared with the antituberculosis drugs streptomycin, isoniazid, rifampin and ethambutol, 5a was determined to be as effective as streptomycin (10 µg/mL) and ethambutol (10.0 µg/kg). Moreover, compounds 4b and 5b were found to be much more effective than streptomycin and ethambutol. Compounds were studied for their antiproliferative effects on breast, colon and prostate cancer cell lines and cancer stem cells derived from these cells. Their effects were also examined on cancer stem cells and the three-dimensional tumor model. Compounds 3, 4b and 5e were found to exhibit antiproliferative effects on breast, colon and prostate cancer and stem cells. Molecular docking studies indicate that these compounds have significant interactions with the active site of the Bcl-2 protein. Compound 3 has the lowest binding energy among the phosphazenes.