Histopathological features of SARS-CoV-2 infection and relationships with organoid technology

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İNANÇ İ., ERDEMLİ E.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.49, sa.9, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 49 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1177/03000605211044382
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: Severe acute respiratory syndrome coronavirus-2, coronavirus disease 2019, histopathology, organoid technology, tissue, organ, CHOROID-PLEXUS, ZIKA VIRUS, STEM-CELLS, COVID-19, ACE2, NEUROTROPISM, CORONAVIRUS, INJURY
  • Ankara Üniversitesi Adresli: Evet

Özet

Coronavirus disease 2019 (COVID-19) following infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a global pandemic that is still having serious effects worldwide. This virus, which targets the lungs in particular, can also damage other tissues. Angiotensin converting enzyme 2 (ACE-2) plays a key role in viral entry into host cells. The presence of ACE-2 in various tissues may permit viral infection. Studies of COVID-19 often make use of postmortem tissues. Although this information provides various useful results, it is also necessary to conduct in vitro studies to understand optimal treatment approaches. Because the virus may show species-specific differences, in vitro technologies using human cells are particularly important. Organoid technologies, three-dimensional structures that can be obtained from human cells, are playing increasingly important roles in studies of SARS-CoV-2. This technology offers a significant advantage in terms of mimicking in vivo tissue structures and testing antiviral compounds. In this mini-review, we summarize studies of SARS-CoV-2 using both histopathological and organoid technology approaches.