Peroxisome proliferator-activated receptor alpha L162V polymorphism in nonalcoholic steatohepatitis and genotype 1 hepatitis C virus-related liver steatosis

Verdi H., Koytak E., Onder O., Cinar K., Idilman R., Erden E., ...Daha Fazla

JOURNAL OF INVESTIGATIVE MEDICINE, cilt.53, sa.7, ss.353-359, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 7
  • Basım Tarihi: 2005
  • Doi Numarası: 10.2310/6650.2005.53706
  • Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.353-359
  • Anahtar Kelimeler: peroxisome proliferator-activated receptor alpha, L162V, polymorphism, fatty liver, nonalcoholic steatohepatitis, hepatitis C virus, ACYL-COA OXIDASE, PPAR-ALPHA, FATTY LIVER, INSULIN-RESISTANCE, METABOLIC SYNDROME, BETA-OXIDATION, MITOCHONDRIAL ABNORMALITIES, DIABETES-MELLITUS, ASSOCIATION, GENE
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Peroxisome proliferator-activated receptor a (PPAR alpha) plays important roles in lipid metabolism. A recently discovered L162V polymorphism of the PPARa gene is associated with enhanced transcriptional activity. In this study, the frequency of L162V was investigated in nonalcoholic steatohepatitis (NASH) and genotype 1 hepatitis C virus (HCV)-related liver steatosis.