Akademik Veri Yönetim Sistemi
Turk Oftalmoloji Gazetesi, cilt.24, sa.4, ss.314-317, 1994 (Scopus)
The efficacy of subconjunctival and intravenous administration routes for ceftazidime was studied in a rabbit model. Five rabbits were given intravenous ceftazidime (50 mg/kg) while ten eyes of another five rabbits received subconjunctival injections of 100 mg of the drug. Two rabbits received balanced salt solution intravenously and served as controls for the intravenous group. Subconjunctival injections of balanced salt solution were made in another two rabbits assigned to the control of the subconjunctival group. Humor aqueous samples were drawn at thee first, second and fourth hours after and ceftazidime levels in the humor aqueous were analyzed using the agar gel diffusion bioassay method. Ceftazidime concentrates in the aqueous humor of the rabbit within 1 to 3 hours upon administration in both subconjunctival and intravenous groups but the inhibitory concentration in the subconjunctival group is higher and lasts longer beyond the fourth hour.