Synthesis and hypoglycemic activity of some new flavone derivatives - 4th Communication: 6-Flavonyl-2,4-thiazolidinediones

Bozdag-Dundar O., Waheed A., Verspohl E., Ertan R.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.51, sa.8, ss.623-627, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 8
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1055/s-0031-1300091
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.623-627
  • Anahtar Kelimeler: antidiabetic agents, flavone derivatives, 2,4-Thiazolidinediones, hypoglycemic activity, synthesis, SUBSTITUTED THIAZOLIDINEDIONES, NIDDM, PATHOGENESIS
  • Ankara Üniversitesi Adresli: Evet

Özet

A new series of flavonyl compounds (1-10) was prepared and tested for their insulinotropic activities in INS-1 cells. Compounds 2, 5 and 6 (at higher concentrations) and compounds 3 and 7-10 were able to increase insulin release in the presence of 5.6 mmol/l glucose at both concentrations used (I and 10 mug/ml).