Serum Apelin-13 Levels Are Decreased Among Adolescents Diagnosed with Major Depressive Disorder

AÇIKEL S. B., Artik A., Hosoglu E., Yerlikaya F. H.

Psychiatria Danubina, cilt.34, sa.4, ss.677-681, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.24869/psyd.2022.677
  • Dergi Adı: Psychiatria Danubina
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, EMBASE, Psycinfo, Social services abstracts
  • Sayfa Sayıları: ss.677-681
  • Ankara Üniversitesi Adresli: Evet

Özet

BACKGROUND: Apelin-13 have potential effect on mood because of high expression in the hypothalamus. In this study, we aimed to investigate the serum apelin-13 levels among adolescents with major depressive disorder. SUBJECT AND METHODS: A total of 42 patients between the ages of 12 and 18 with a primary diagnosis of major depressive disorder have been included. Depression scores of both groups were measured by the Children's Depression Inventory. Serum apelin-13 concentrations were measured by a commercially available kit based on enzyme-linked immunosorbent assay (ELISA) method. RESULTS: The mean serum apelin-13 levels in the patients with MDD was 173.08±106.33 pg/ml, whereas it was 251.75±167.82 pg/ml in healthy controls. The difference between groups in terms of mean serum apelin-13 levels was statistically significant (p=0.018, Cohen's d=-0.571). CONCLUSION: This is the first study to examine the serum apelin-13 levels in adolescents diagnosed with major depressive disorder. Lower serum apelin-13 levels were found in depressed adolescents.