Molecular Screening of LFS and PSSM-I Diseases in Arabian Horse Population in Turkey

BİLGEN N., ÇINAR KUL B., Ertugrul O., Erzurum F.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.23, sa.2, ss.339-342, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.9775/kvfd.2016.16213
  • Dergi Adı: KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.339-342
  • Anahtar Kelimeler: Arabian horses, LFS, PCR-RFLP, PSSM-I, MUTATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Polysaccharide Storage Myopathy (PSSM) and Lavender Foal Syndrome (LFS) are inherited diseases in horse. PSSM-I, a point mutation in Glycogen Synthase-1 gen (GYS1) causes increased activation of the enzyme and abnormal polysaccharides formation. LFS caused by one nucleotide deletion in Myosin-Va (MYO5A) leads frame shift mutation and premature termination of the protein. In the study, a total of 239 blood samples, taken from Anadolu (n=70), Karacabey (n=70) and Sultansuyu (n=99) stud farms were screened. Diseases related mutations were not detected in the sampled Arabian horse population.