Antioxidant activity of N-substituted indole 2- and 3-carboxamides

---

Ölgen S., ÇOBAN T.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.33, sa.2, ss.109-116, 2004 (Scopus, TRDizin)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 33 Sayı: 2
• Basım Tarihi: 2004
• Doi Numarası: 10.1501/eczfak_0000000404
• Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
• Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.109-116
• Anahtar Kelimeler: Antioxidant activity, Lipid peroxidation, N-substituted and N-H indole amide derivatives, Superoxide dismutases
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Ankara Üniversitesi Adresli: Evet

Özet

A series of N-substituted indole amide derivatives was tested for in vitro effects on rat liver mlcrosomal NADPH-dependent lipid peroxidation (LP) and superoxide anion (SOD) formation. Vitamin E (α-tocopherol) decreased the LP level by about 63% at 10-4 M concentration. A significant decrease in male liver microsomal LP level was noted for the compounds 1, 8 and 10 at a concentration of 10-4 M comparing with α-tocopherol. The inhibition of O2<- by compounds 8 and 10 were found highly efficient. Both activity results show that these compounds are promising antioxidants.