Antioxidant activity of N-substituted indole 2- and 3-carboxamides
Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.33, no.2, pp.109-116, 2004 (Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 33 Issue: 2
- Publication Date: 2004
- Doi Number: 10.1501/eczfak_0000000404
- Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.109-116
- Keywords: Antioxidant activity, Lipid peroxidation, N-substituted and N-H indole amide derivatives, Superoxide dismutases
- Open Archive Collection: AVESIS Open Access Collection
- Ankara University Affiliated: Yes
Abstract
A series of N-substituted indole amide derivatives was tested for in vitro effects on rat liver mlcrosomal NADPH-dependent lipid peroxidation (LP) and superoxide anion (SOD) formation. Vitamin E (α-tocopherol) decreased the LP level by about 63% at 10-4 M concentration. A significant decrease in male liver microsomal LP level was noted for the compounds 1, 8 and 10 at a concentration of 10-4 M comparing with α-tocopherol. The inhibition of O2<- by compounds 8 and 10 were found highly efficient. Both activity results show that these compounds are promising antioxidants.