Assessment of Colistin Treatment in Multidrug-Resistant Gram-Negative Bacterial Infections

Coskun B., AZAP A., Yilmaz G., Ayhan M., Saricaoglu E. M.

KLIMIK JOURNAL, cilt.33, sa.2, ss.142-147, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5152/kd.2020.30
  • Dergi Adı: KLIMIK JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.142-147
  • Anahtar Kelimeler: Multiple bacterial drug resistance, colistimethate sodium, colistin, nephrotoxicity, RISK-FACTORS, NEPHROTOXICITY, BAUMANNII, PHARMACODYNAMICS, PHARMACOKINETICS
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Colistin is a concentration-dependent antibiotic which belongs to the polymyxin group of cyclic cationic polypeptide antibiotics. Clinical use of colistin varies due to its complex pharmacokinetic and pharmacodynamic features. In this study, we aimed to evaluate the use of colistin in multidrug-resistant Gram-negative bacterial infections.